ABSTRACT
Background:Colorectal polyps(CRP)has nonspecific clinical manifestation,and is closely related to the pathogenesis of colorectal cancer. Studies have shown that abnormalities of serum uric acid(UA),serum lipids are closely related to pathogenesis of CRP,but is still in controversial. Aims:To investigate the correlation between serum UA,TG, TC,LDL-C,HDL-C and incidence of CRP. Methods:A total of 142 CRP patients from Jan. 2016 to Oct. 2016 at Qingdao Municipal Hospital were enrolled,and 116 patients without CRP were served as controls. The serum levels of UA, TG,TC,LDL-C,HDL-C were determined,and correlation between UA and serum lipids was analyzed. Results:Compared with controls,serum levels of TG,UA were significantly increased in CRP patients(P<0.05),HDL-C level was significantly decreased(P<0.05),however,no significant differences in TC,LDL-C levels were found between the two groups. Serum UA level was positively correlated to TG,TC,LDL-C levels in patients with CRP(r=0.32,r=0.21, r=0.15;P<0.05),and negatively correlated to HDL-C level(r= -0.07,P<0.05). Conclusions:Increased serum TG and UA levels and decreased serum HDL-C level may be correlated to the pathogenesis of CRP. The interaction between serum UA,TG,TC,LDL-C and HDL-C may increase the risk of CRP.
ABSTRACT
Objective To investigate the effect of Williams life skills training (WLST) on preoperative anxiety and trait coping strategies in patients undergoing general anesthesia for elective surgery. Methods A total of 120 patients undergoing general anesthesia for elective surgery were randomly divided into observation group and control group according to random number table method with 60 cases each. The control group was given general preoperative nursing intervention, on the basis of which the observation group gave WLST. Before and after the intervention, the Amsterdam Preoperative Anxiety and Information Scale and Trait Coping Style Questionnaire were used to evaluate the patients. Results Before intervention, there was no significant difference between the two groups (P>0.05). After intervention, the preoperative anxiety and information needs scores of the observation group was (10.02 ± 2.53) and (4.02 ± 1.05) points respectively, while in the control group was (15.89 ± 3.20) and (7.96 ± 1.62) points respectively, the difference was statistically significant (t=7.952, 8.447, P<0.05), and negative coping score was (29.07 ± 6.14) points lower than the control group (33.86 ± 7.12) points, positive response score was (33.89 ± 7.64) points higher than the control group (29.77 ± 6.71) points, the difference was statistically significant (t = 7.647, 7.981, P <0.05). Conclusion WLST can effectively improve preoperative anxiety in patients undergoing general anesthesia and improve their coping ability, which is conducive to the successful implementation of anesthesia and surgery.